Tumor‐specific CD 4 + T cells maintain effector and memory tumor‐specific CD 8 + T cells

Rapid Effector Function in CD 8 1 Memory T Cells

The nature of the CD8 1 T cells that underlie antiviral protective immunological memory in vivo is unclear. We have characterized peptide-specific CD8 1 T lymphocytes directly ex vivo from peripheral blood in humans with past exposure to influenza virus, using single cell interferon g (IFNg ) release as a measure of effector function. In individuals in the memory state with respect to influenza...

Cellthe Peripheral Activated / Memory CD 4 T Regulatory CD 4 T Cells Control

Accelerated Help to B Cells Memory CD 4 T Cells

CD4 T cell help for B cells is critical for effective Ab responses. Although many of the molecules involved in helper functions of naive CD4 T cells have been characterized, much less is known about the helper capabilities of memory CD4 T cells, an important consideration for the design of vaccines that aim to prime protective memory CD4 T cells. In this study, we demonstrate that memory CD4 T ...

Accumulation of Effector CD 4 T Cells during

Double - Negative ( CD 4 - CD 8 - ) T Cells From Adult T - ce l l Leukemia Patients

We present four patients with adult T-cell leukemia (ATL) derived from a novel T-cell subset (CD4-, CD8[doublenegative, DN], T-cell receptor [TCR] &). In the ATL cells of these patients, neither gene nor surface expression of CD4 and CD8 antigens was detected. Clinical and laboratory data showed no difference between DN-ATL and CD4+ATL patients. In contrast to typical CD4+ATL cells, DN-ATL cell...